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    • Application
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    • Direct vs indirect
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      software
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  • Literature
  • Events
  • Glossary
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Application
range

Types of
OSeeT systems

Direct vs indirect
measurements

OSeeT
software

OSeeT

OSeeT – Optical Coherence Tomography for the in-line and at-line monitoring of pharmaceutical products and their critical quality attributes.

OSeeT is the only existing technology that allows rapid (even in-line/real-time) monitoring of coating quality without calibration and multivariate data analysis for transparent and semi-transparent materials.

OSeeT provides direct information about multiple quality attributes of layers in pharmaceutical products (e.g. coating thickness) and is a link to related critical quality attributes (e.g. API release in dissolution).

OSeeT can also provide indirect information (for scattering materials) from the penetration depth of light into the sample which can be linked e.g. to dissolution behavior or compression force.

Working
principle

• OCT is based on (coherence gated) interferometry.
• Light is split in reference and probe path.
• Optics of the sample arm focus light and define lateral (=surface) resolution in focus.
• Interference of light reflected back from both paths.
• Spectrometer (grating, high-speed CMOS sensor).
• Depth-information is generated from interference by non- linear Fourier-transformation (nu-FFT).
• Depth scan measurement rate: 130 – 250 kHz (depending on OSeeT system version).
• Direct thickness measurement (optical path length).
• Each interferogram -> one depth reading (“A-scan”, 1D). A-scan rate: 130kHz-250kHz max.
• Multiple A-scans -> cross-sectional image (“B-scan”, 2D). Requires moving of objects or a scanning sensor beam.

Gallery/Use cases/installation examples

OSeeT Pharma 1D with Sampling device

Gallery/Use cases/Installation examples

OSeeT Pharma 1D with Sampling device

Fluid bed probe installed in-line

Gallery/Use cases/Installation examples

Fluid bed probe installed in-line

Pan coated probe installed in-line

Gallery/Use cases/Installation examples

Pan coated probe installed in-line

Pan coater probe

Gallery/Use cases/Installation examples

Pan coater probe

Probe installed in Oral Film production machine

Gallery/Use cases/Installation examples

Probe installed in Oral Film production machine

OSeeT image showing the coating and the laser drilled hole in Oros tablet

Gallery/Use cases/Installation examples

OSeeT image showing the coating and the laser drilled hole in Oros tablet

Sampling device SDP2.1 for measuring at-line pellets, tablets, capsules

Gallery/Use cases/Installation examples

Sampling device SDP2.1 for measuring at-line pellets, tablets, capsules

Sampling device SD1 for measuring at-line tablets, capsules mimic a tablet coater

Gallery/Use cases/Installation examples

Sampling device SD1 for measuring at-line tablets, capsules mimic a tablet coater

OSeeT image of pellets at-line

Gallery/Use cases/Installation examples

OSeeT image of pellets at-line

Screen shot visualisation of a complete coating process

Gallery/Use cases/Installation examples

Screen shot visualisation of a complete coating process

Screen shot visualisation of a trend of a complete coating process

Gallery/Use cases/Installation examples

Screen shot visualisation of a trend of a complete coating process

OSeeT image of Multi-layer pellets with UHR -OSeeT

Gallery/Use cases/Installation examples

OSeeT image of Multi-layer pellets with UHR -OSeeT

OSeeT image of 6 microns coating layer with UHR-OSeeT

Gallery/Use cases/Installation examples

OSeeT image of 6 microns coating layer with UHR-OSeeT

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